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Chemical Data :

IUPAC: naphthalen-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate

CAS: N/A

Molecular Weight: 375.4

Molecular Formula: C24H22FNO2

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Description

NM-2201

NM-2201

NM-2201 (also known as CBL-2201) is an indole-based synthetic cannabinoid that is presumably a full agonist and unselectively binds to CB1 and CB2 receptors with low nanomolar affinity. Little to no research data available on this chemical makes it impossible to describe it’s properties in detail.

However, it is an analogue of another synthetic cannabinoid AM-2201, meaning it might share some similarities. This drug was discovered by Alexandros Makriyannis from Northeastern University. It has been told by users that this drug is the most potent chemical from these types of drugs. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications.

Its official designation in the IUPAC system is defined naphthalen-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate , and simple chemical formula of the substance is summed up as C24H22FNO2 , with the molecular weight determined to be 375.4 g/mol.

Solvents as ethanol,DMSO, dichloromethane and dimethylformamide purged with a inert gas.NM-2201 is sparingly soluble in aqueous solutions.To enhance aqueous solubilty, dilute the organic solvent solution into aqueous buffers or isotonic saline.If performing biological experiments,ensure the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects on low concentrations. . It is not recommended storing the aqueous solution for more than one day.

This drug is, however, used as a recreational drug and those who have used it testify that this is one of the best cannabinoids when it comes to euphoric experiences. The drug is typically sprayed on botanical material and smoked, although it can be ingested in liquid or powder form.
To learn the characteristics of NM-2011 one can refer to the characteristics of AM-2201. AM-2201 is a drug whose chemical properties have been studied. However, specific toxicity and chemical properties of NM-2201are not available.

Users of this drug have testified that there are very little side effects to the drug; there is no nausea or panic attacks when coming down or during the peak. The drug has a quick and strong effect. It can be burnt and smoked. There is an effect of mild disassociation with its use. The effects will not last that much but it is potent.

The powder of NM-2201 will quickly burn under fire; users then smoke the contents. Thissynthetic cannabinoid is usually taken in doses of 5 mg or a little more than 10 mg. This amount required is a lot less than other artificial cannabinoids, which poses a problem of very frequent overdose. The usual amount used is around 2 mg. The drug acts as an agonist to the central cannabinoid (CB1) and the peripheral cannabinoid (CB2) receptors.

Effects caused by this drug after usage include panic and anxiety attacks. With very small doses, as small as 2mg, some people might experience nausea. There are reports of convulsions being caused by doses of 10 mg. This drug is so potent that a sample as small as 500µg is completely active. Once the drug is manufactured, it can remain stable for about one year.

This item was created exclusively for research purposes. However, many people have used it for recreational purposes. There is very little documentation about the experiences of users and the aftermath, if any.

Unverified sources report :”I received 5gm of NM-2201 for research and I must say WOW! This is the best cannabiniod since JWH-018, and I’ve tried a lot of different synthetics out there since the ban. Comes on quick and strong and even causes a bit of mild disassociation like a weak dose of MXE. Seems to be a strong, if not full, agonist at both CB1 and CB2 cannabinoid receptors. It might not last quite as long as JWH-018 but it certainly is potent. My ROA is using the tip of an Exacto knife blade to dump an eyeballed amount on top of a piece of red hot hooka charcoal and inhaling the smoke using a glass tube. This results in a fast and complete burn. I’ve been using hooka charcoal since the late 70’s when I first used it for smoking Jamaican hash oil. It can be used for any RC, or any drug for that matter, that requires smoking.”
NM-2201 is banned in Sweden and Germany.

Names and identifiers of NM-2201

1-(5-Fluoropentyl)-1H-indole-3-carboxylate de 1-naphtyle [French] [ACD/IUPAC Name]
1H-Indole-3-carboxylic acid, 1-(5-fluoropentyl)-, 1-naphthalenyl ester [ACD/Index Name]
1-Naphthyl 1-(5-fluoropentyl)-1H-indole-3-carboxylate [ACD/IUPAC Name]
1-Naphthyl-1-(5-fluorpentyl)-1H-indol-3-carboxylat [German] [ACD/IUPAC Name]
1-(5-Fluoro-pentyl)-1H-indole-3-carboxylic acid naphthalen-1-yl ester
837122-21-7
naphthalen-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate
NM2201

Chemical Data of NM-2201

Density: 1.2±0.1 g/cm3
Boiling Point: 565.2±30.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.5 mmHg at 25°C
Enthalpy of Vaporization: 84.9±3.0 kJ/mol
Flash Point: 295.6±24.6 °C
Index of Refraction: 1.592
Molar Refractivity: 109.0±0.5 cm3
#H bond acceptors: 3
#H bond donors: 0
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 1
ACD/LogP: 6.49
ACD/LogD (pH 5.5): 5.75
ACD/BCF (pH 5.5): 13832.67
ACD/KOC (pH 5.5): 32036.73
ACD/LogD (pH 7.4): 5.75
ACD/BCF (pH 7.4): 13832.67
ACD/KOC (pH 7.4): 32036.73
Polar Surface Area: 31 Å2
Polarizability: 43.2±0.5 10-24cm3
Surface Tension: 42.2±7.0 dyne/cm
Molar Volume: 322.2±7.0 cm3

Smiles: FCCCCCN1C=C(C(=O)OC2=CC=CC3=CC=CC=C23)C2=CC=CC=C12

InChI: 1S/C24H22FNO2/c25-15-6-1-7-16-26-17-21(20-12-4-5-13-22(20)26)24(27)28-23-14-8-10-18-9-2-3-11-19(18)23/h2-5,8-14,17H,1,6-7,15-16H2

InChI key: PRGFSQYZCKCBQO-UHFFFAOYSA-N

Formula: C24H22FNO2
Isotope formula: C24H22FNO2
Composition: C (76.78%), H (5.91%), F (5.06%), N (3.73%), O (8.52%)
Isotope composition: C (76.78%), H (5.91%), F (5.06%), N (3.73%), O (8.52%)
Mass: 375.4354
Exact mass: 375.163457158

Atom count: 50
Bond count: 53
Cyclomatic number: 4
Chain atom count: 9
Chain bond count: 10
Asymmetric atom count: 0
Rotatable bond count: 8
FSP3: 0.21

Ring Count: 4
Ring atom count: 19
Ring bond count: 21
Aliphatic ring count: 0
Aromatic ring count: 4
Aliphatic atom count: 9
Aliphatic bond count: 10
Aromatic atom count: 19
Aromatic bond count: 21
Carbo ring count: 3
Hetero ring count: 1
Heteroaromatic ring count: 1
Carboaromatic ring count: 3
Fused ring count: 4
Fused aliphatic ring count: 0
Fused aromatic ring count: 4
Largest ring size: 6
Smallest ring size: 5

Platt index: 84
Randic index: 13.78
Balaban index: 1.30
Harary index: 107.15
Wiener index: 2150
Hyper Wiener index: 9184
Wiener polarity: 44
Szeged index: 3239

Lipinski’s rule of five: no
Bioavailability: yes
Ghose filter: no
Lead likeness: no
Muegge filter: no
Veber filter: yes

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